A study of growth
hormone release in man after oral administration of amino acids.
Isidori A, Lo Monaco A, Cappa M.
A study was carried out in 15 male
volunteers to evaluate qualitatively the secretion of growth factors following
stimulation by oral amino acids. The results showed that oral administration
of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine)
provoked a release of pituitary somatotropin and insulin. This phenomenon was
reproducible and the growth hormone secreted in response to this stimulation
had biological activity (as demonstrated by a radioreceptor assay and somatomedin
induction). The effect appeared to be specific to the combination of the two
amino acids; neither of the amino acids demonstrated appreciable stimulating
activity when administered alone, even at the same doses.
1: Curr Med Res Opin 1981;7(7):475-81
PMID: 6790230 [PubMed - indexed for